Resorbable mesh is used in a wide variety of applications, providing containment and support, or acting as a tissue scaffold to support the healing process. Within orthopaedics, resorbable mesh holds in place bone grafts, bone graft substitute and bone fragments; while it is used in Sport Medicine for tendon reinforcement, as an adjunct to suture anchor repair.
The ResorbMESH product platform can be tailored to meet these applications. For Orthopaedics, a condensed, low profile, macroporous design, delivers a high strength resorbable mesh. By using proven resorbable material combinations of PLA, PGA, and PCL, the strength and degradation is controlled, while ensuring minimal inflammatory biologic response. The thin 2D mesh design can then be conformed to match a desired anatomical shape, while for Sports Medicine indications the resorbable surgical mesh wraps easily around damaged or torn tissue ahead of suture fixation.
ResorbMEM is a fully resorbable 3D membrane or scaffold, which can be designed for use in Orthopaedics and Sports Medicine. The scaffold design is customised to optimally facilitate the natural regeneration of tissue. Important considerations in scaffold design include:
- Mechanical properties e.g. scaffold stiffness/ material modulus.
- Degradation – rate of material resorption, in relation to regeneration rate of local tissue.
- Pore architecture – selection of pore size and distribution appropriate to local cell type.
The ResorbMEM scaffold is formed from individual precision micro-machined layers, using CAD-CAM guided processing. 3-D scaffolds are achieved through careful pore registration between multiple layers. Surface physical patterning and/ or functionalised chemistries may be applied, to encourage improved healing regimes. In this way, cell attachment, growth, proliferation and differentiation can be improved, yielding enhanced regeneration of native tissue types.
Furthermore, our biomaterial scaffold technology has potential use in the controlled release of drugs, cellular components and growth factors. The use of the biomaterial scaffold/matrix permits a locally targeted, optimal release profile of delivery agents.
This article was orininally published at: http://proxybiomedical.com/resorbable-surgical-mesh/